| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed3b1ee1e04d60cf850836bbdccd320b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-802
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-822
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2474-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2469-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-205
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56922
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56916
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-107 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 |
| filingDate |
1997-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_517de9d650ebaa1a4f9c3caa70a10975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7914fdb5cfc2fb2d96068cf98c83c125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e27ac12674208c40b371a206707c3c67 |
| publicationDate |
1999-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5869066-A |
| titleOfInvention |
Vaccine containing a campylobacter bacterium having an enhanced antigenic property |
| abstract |
This invention relates generally to in vitro methods for inducing or enhancing expression of enteric bacterial antigens and/or virulence factors thereby producing antigenically enhanced enteric bacteria, to methods for using antigenically enhanced enteric bacteria and to vaccines comprising antigenically enhanced enteric bacteria. Further, a vaccine comprising a Campylobacter bacterium having en enhanced antigenic property is disclosed. The culture medium conditions comprise 0.05% to 3% bile or 0.025% to 0.6% of one or more bile acids or salts. In addition a divalent cation chelator can also be included in the culture medium. The bacteria culture is in a growth phase at early log phase and between early log phase and stationary phase. The enhanced antigenic property is a higher level of an immunogenic antigen when compared to the antigenic property of the same bacteria grown on brain heart infusion broth. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722123-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7700578-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9925254-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9308246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009004223-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007108903-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004048597-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8440448-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009098157-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7575744-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5976525-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10500261-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007104731-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011054026-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006073129-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010074846-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007110765-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007038122-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007243204-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005095682-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004048597-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11406702-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2006295017-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011300173-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8329192-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6663873-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973908-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10086059-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6087105-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007065461-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7901907-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9084809-B2 |
| priorityDate |
1994-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |