| abstract |
PCT No. PCT/US94/08868 Sec. 371 Date Jan. 11, 1996 Sec. 102(e) Date Jan. 11, 1996 PCT Filed Aug. 8, 1994 PCT Pub. No. WO95/05192 PCT Pub. Date Feb. 23, 1995 <IMAGE> (I) This invention relates to substituted ketone derivatives of formula (I) useful in the treatment of inflammation in lung, central nervous system, kidney, joints, endocardium, pericardium, eyes, ears, skin, gastrointestinal tract and urogenital system. More particularly, this invention relates to substituted ketone drivatives that are useful inhibitors of interleukin-1 beta converting enzyme (ICE). Interleukin-1 beta converting enzyme (ICE) has been identified as the enzyme responsible for converting precursor interleukin-1 beta (IL-1 beta ) to biologically active IL-1 beta . |