http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5861477-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6456 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2462 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate | 1994-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_006fb24b6ddf1369dfd7d2e0f3896b4e |
| publicationDate | 1999-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5861477-A |
| titleOfInvention | Cyclic peptide catalysts modeled on enzyme active sites |
| abstract | PCT No. PCT/US94/05569 Sec. 371 Date Jun. 19, 1996 Sec. 102(e) Date Jun. 19, 1996 PCT Filed May 18, 1994 PCT Pub. No. WO94/28018 PCT Pub. Date Dec. 8, 1994PEPZYMES TM , chemically synthesized cyclic peptides, modeled on the active sites of naturally-occurring enzymes represented by chymotrypsin, trypsin, lysozyme, ribonuclease, urokinase, tissue plasminogen activator and their analogs are disclosed. The conformational constraints imposed on the peptide residues cause the amino acids of the peptide to assume a three-dimensional spatial relationship relative to the substrate that is essentially equivalent to that of the corresponding active site amino acids of the natural enzyme in its catalytically active state. The new cyclic peptides catalyze the same reaction as the native enzyme being modeled, but have amino acid sequences that are substantially shorter than the naturally-occurring enzymes, and do not occur in the same linear relationship in the naturally-occurring enzymes. Methods of producing PEPZYMES TM are described. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004192611-A1 |
| priorityDate | 1993-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 125.