| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1994-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9a7e331dc7038f31d791a3eb3fbb454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6efa7b6d85e434177303d4cd6986c28 |
| publicationDate |
1999-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5856454-A |
| titleOfInvention |
CDNA for human and pig dihydropyrimidine dehydrogenase |
| abstract |
The invention relates to methods and compositions that are useful for detecting deficiencies in dihydropyrimidine dehydrogenase (DPD) levels in mammals including humans. Cancer patients having a DPD deficiency are at risk of a severe toxic reaction to the commonly used anticancer agent 5-fluorouracil (5-FU). Claimed are DPD genes from human and pig, methods for detecting the level of nucleic acids that encode DPD in a patient, and nucleic acids that are useful as probes for this purpose. Also claimed are methods for expressing DPD in heterologous organisms. Expression vectors that employ a DPD nucleic acid as a selectable marker are also claimed. This selectable marker functions in both prokaryotes and eukaryotes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7402387-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003148403-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009280537-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009039136-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011049956-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003022246-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4690446-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002123620-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011062212-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7005278-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011049956-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003148402-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003148543-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1840660-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005136433-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6905821-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6956111-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6787306-B1 |
| priorityDate |
1994-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |