http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5854391-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 |
| filingDate | 1993-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_076d8811c5b2bb3c5a63444d3245978d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d61e129e5c68f18b7e3e0acb3e383de |
| publicationDate | 1998-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5854391-A |
| titleOfInvention | Glycosylation of peptides using glycosyl phosphite reagents |
| abstract | A method for synthesizing glycosylated peptides employs a blocked carbohydrate donor and a blocked peptide acceptor. The carbohydrate donor includes an acid labile phosphite leaving group attached to the anomeric carbon. The blocked peptide acceptor includes an unprotected hydroxyl group susceptible to electrophilic attack. Serine hydroxyl is preferred. The reaction is initiated by the addition of a Lewis acid so as to activate the acid labile phosphite leaving group on the carbohydrate donor. The substitution reaction may be conducted at -78° C. in a solvent such as Et 3 N which favors the formation of glycosylated peptide products. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010118384-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9371599-B2 |
| priorityDate | 1993-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.