http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5852198-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ec46f41b6433509cc8a9750ffcf0afd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5352 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate | 1997-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88b8d55658084edd4b95816ea54b16a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff4e3441e10b7b78762ae645f12ad425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8007424ee9d18b76ae4bb94164c3bce |
| publicationDate | 1998-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5852198-A |
| titleOfInvention | Wittig reagents and method for preparing α,β-unsaturated phosphonates |
| abstract | Wittig-type reagents and methods of preparation and use thereof for preparing alpha , beta -unsaturated phosphonate esters from aldehydes and ketones are disclosed. The Wittig-type reagents have the following formulae: <IMAGE> I <IMAGE> II wherein X represents triflate, halide, BF4, SbF6, or ClO4; R1 represents alkyl, aryl or arylalkyl; and R2 represents alkyl, aryl or arylalkyl, provided that R1 and R2 not represent phenyl at the same time. The Wittig reagent diethyl phosphono-methylidenetriphenylphosphorane (1b) has been successfully synthesized for the first time via its phosphonium triflate salt (4a), by treating diethyl phosphonomethyltriflate with triphenylphosphine according to the disclosed method. The procedure has been applied to the synthesis of other new Wittig-type reagents such as phosphoranes and phosphonium salts. The new Wittig reagents thus synthesized were treated with various aldehydes and an activated ketone, affording the corresponding alpha , beta -unsaturated phosphonates, saturated phosphonates or phosphoric acids. Triphenylphosphorane 1b and triphenylphosphonium 4a led to both cis and trans isomers with the latter being predominant, while trans isomers were almost exclusively formed when tributyl reagents (1c and 4d) were used. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021612-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7235688-B1 |
| priorityDate | 1996-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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