| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8846b94c975f7911d2495e0261c466f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a112fa5dd8cc717ee8bdb5e4004d0b0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
1996-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18148babc0df42af804590ed7071430d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_769603e75b36a4729cd00a86a6108020 |
| publicationDate |
1998-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5849999-A |
| titleOfInvention |
Transgenic non-human mice expressing Flag-APP-C100 protein develop alzheimer's disease brain morphology and behavior |
| abstract |
Disclosed is a transgenic non-human mammal that expresses in its brain a transgene encoding an APP-C100 polypeptide with the flag amino acid sequence fused to the amino terminus of the APP-C100. This transgenic non-human mammal is an improved in vivo model for Alzheimer's disease-like neuropathology and associated cognitive impairment. The improvement includes accelerated development of AD-like neuropathology and cognitive impairment. The AD-like neurodegeneration and associated cognitive impairment in mice produced according to this invention appear at least six months sooner than they appear in APP-C100-expressing transgenic mice. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3730188-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6670195-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008112903-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006117397-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011023152-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8283517-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009098052-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021138568-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017035017-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003199003-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016077078-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6673600-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009105590-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009140679-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017035010-A1 |
| priorityDate |
1996-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |