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filingDate 1995-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1998-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f97e1824966747d20f55be5d9d5141ec
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publicationDate 1998-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5849189-A
titleOfInvention Hollow fiber blood purifying membrane and process for its production
abstract PCT No. PCT/JP95/00339 Sec. 371 Date Nov. 6, 1995 Sec. 102(e) Date Nov. 6, 1995 PCT Filed Mar. 2, 1995 PCT Pub. No. WO95/24262 PCT Pub. Date Sep. 14, 1995A hollow fiber blood purifying membrane which is a hollow fiber membrane substantially composed of cellulose acetate, has a substantially non-oriented distribution of cellulose acetate polymer particles on the inner surface of the hollow fibers, has a dense layer with a thickness in the range of 30-1000 nm on both the inner and outer surface of the hollow fibers and a porous structure which is substantially uniform at the membrane wall between the two dense layers, and has an in vitro ultrafiltration rate (UFR) of 10 to 50 ml/m2xmmHgxhr and a (in vivo UFR)/(in vitro UFR) ratio of at least 0.3, a blood plasma albumin permeation blockage of at least 90%, and an in vivo beta 2-microglobulin ( beta 2-MG) sieving coefficient of at least 0.4, as well as a process for its production.
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