| abstract |
PCT No. PCT/US93/12161 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Dec. 14, 1993 PCT Pub. No. WO94/13303 PCT Pub. Date Jun. 23, 1994A method and pharmaceutical preparation are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The method comprises administering to a patient having such a pathological condition an oligonucleotide antisense to one or more RNA molecules encoding one of the several dopamine receptors. The antisense oligonucleotides bind specifically to expression-controlling sequences of such RNA molecules, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression. |