http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5837807-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 1996-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a578426d119f5a731b9ce2e76297e990 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18694476cf34b7f565e8089099ad3008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcf2a903fc9c1d5f175fae46c46a2493 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a205029340d85b28caaf8fd0413c891 |
| publicationDate | 1998-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5837807-A |
| titleOfInvention | Tetrahydronaphthalene compounds |
| abstract | This invention is directed to tetrahydronaphthalene compounds of the formula <IMAGE> Ia <IMAGE> Ib wherein R1 is hydrogen, bromine, cyano, formyl, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, aryloxy, lower aralkoxy or aryl; R2 is an amino acid residue or a chain of 2 to 20 amino acid residues wherein reactive moieties in the side chains of the amino acid residue(s) is/are protected or unprotected, and wherein the amino group of the N-terminal amino acid is a free or protected amino group; A1, A2, A3 and A4 each are alpha -amino acid residues wherein A1 and A2 are in the L configuration and A3 and A4 are in the D configuration when the alpha -C atom of said alpha -amino acid residue is asymmetric; X is oxygen or sulphur; Y is a residue of the formula <IMAGE> (a) <IMAGE> (b) n is 0 or 1; R3 is hydrogen or lower alkyl; R4 is hydrogen or lower alkyl; and Z and the two C atoms together are an aromatic ring selected from the group of benzene, furan, thiophene, pyridine or pyrimidine, wherein said aromatic ring is substituted or unsubstituted; and salts thereof and their intermediates. The compounds are useful as mimetics of exposed helical domains of proteins in order to clarify their role with respect to interactions with other proteins or with DNA or RNA through alpha -helical conformation. They are therefore valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are also potentially useful as medicaments. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8481725-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6439963-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009111983-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009137799-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009156805-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8829209-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8957205-B2 |
| priorityDate | 1995-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 633.