Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ebb6a553affdc364c91cffe3baf12564 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-66 |
filingDate |
1997-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
1998-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc8612094babedbdd74ce41b99cb7c9d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a63550f7b7bca5932a200ef48d02e6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ac5414785e5db896dbfb95b484940cc |
publicationDate |
1998-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-5817823-A |
titleOfInvention |
Method for synthesizing 2-substituted imidazoles |
abstract |
The present invention is a method of preparing 2-substituted imidazoles from readily available imidazoles having a leaving group in the 2-position, by alkylating the imidazole under mild conditions to afford a 3-N-alkylated imidazolium salt; and coupling the imidazolium salt with a nucleophile also under mild conditions to afford a 2-substituted 3-N-alkylated imidazolium salt. The reaction product can optionally be isolated and purified. The 2-substituted 3-N-alkylated imidazolium salt is hydrolyzed to afford a 2-substituted imidazole. Alternatively, the imidazole is coupled with a nucleophile in the presence of fluoride ion to provide a 2-substituted imidazole. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8039637-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007021386-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9598375-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6262100-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7714013-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7737285-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009035302-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10363241-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101248060-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007002157-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004082542-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03008408-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010145065-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9024040-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7361678-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6627646-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010256119-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501956-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8383832-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8580833-B2 |
priorityDate |
1997-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |