| abstract |
PCT No. PCT/JP95/02400 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Nov. 27, 1995 PCT Pub. No. WO96/16938 PCT Pub. Date Jun. 6, 1996An indole derivative of the formula: <IMAGE>l-lower alkoxy, carboxy-lower alkoxy, lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower alkylaminosulfonyl, etc., R2 is hydrogen, halogen, lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, etc., R3 is hydrogen or lower alkyl, R4 is halogen or trifluoromethyl, R5 is lower alkyl, or a salt thereof, these compounds being potent beta 3-adrenergic receptor-stimulating agent with excellent adrenoceptor selectivity, and being useful in the prophylaxis or treatment of obesity or diabetes mellitus. |