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filingDate 1995-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1998-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1998-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5814716-A
titleOfInvention Cell lines from a transgenic mouse which express biologically active IX factor
abstract Cell lines have been prepared from transgenic mice comprised of a first exogenous DNA sequence encoding human factor IX which is controlled by a promoter region specific for hepatic cells and a second exogenous DNA sequence encoding an oncogene, such as the SV40 virus gene encoding the T-antigen or the mouse c-myc gene, which is controlled by a promoter region specific for hepatic cells. Promoter regions specific for hepatic cells included the promoter region for the factor IX gene and the promoter region for the alpha -1 antitrypsin gene. The cultured cells produce biologically active human factor IX which is then isolated from the culture media.
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