| abstract |
The invention provides a compound which has anti-ulcer effect and antibacterial activity against Helicobacter pyroli. This compound is an alkylenediamine derivative or salt which has a general formula of (1): <IMAGE> formula 1 wherein each of R4, R5, and R6 is hydrogen or lower alkyl; n represents an integer of 1 to 6; Y is -CH2-, -O-, or -N(R7)-, wherein R7 is lower alkyl, aryl, carbamoyl lower alkyl, aralkyl, or a heterocyclic group having 5 to 9 carbon numbers; and, W is a group expressed by formulas 2 or 3: <IMAGE> formula 2 <IMAGE> formula 3 wherein (1) in formula 2: each of R1 and R2 is hydrogen, lower alkoxy, alkenyloxy, or a halogen atom; each of R3 and R3 is methyl, prenyl, or geranyl; when one of R3 and R3 is prenyl or geranyl, the other must be a methyl group; and X is oxygen or sulfur; and (2) in formula 3, R10 is a lower alkyl, and R11 is a halogen atom. |