| abstract |
8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR 4 wherein R 4 is chosen in the group consisting of CHO, COCH 3 , acyl derivative of a carboxylic acid containing up to 6 carbon atoms; n R 1 is chosen in the group consisting of: H, OH, OCH 3 ; n R 2 is chosen in the group consisting of: H, OH, NH 2 n R 3 is chosen in the group consisting of: H, OH, NH 2 , residue of formula (A) ##STR2## The compounds are characterized by having cis-stereochemistry between the groups 8--F and 9--OH. Their preparation and pharmaceutical compositions containing them are also described. |