http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5811540-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8af19d05c71d306141bc1fdbd2f05f39 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-02 |
| filingDate | 1994-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ded5c691c1e7d77e01015b0a29cf7353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de0e0d1233cdb17fa34a096b6fc3ae5d |
| publicationDate | 1998-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5811540-A |
| titleOfInvention | 5-O-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, and production method and use thereof |
| abstract | Disclosed is a 5-O-pyrimidyl-2,3-dideoxy-1-thio-D-furanoside derivative represented by the following formula (I) or an L-form isomer thereof: ##STR1## wherein X represents a hydrogen atom, a fluorine atom or an azido group; R 1 represents a C 1-4 alkyl group; R 2 represents a hydrogen atom, a methyl group or a fluorine atom or a trifluoromethyl group; R 3 represents a C 1-10 alkyl group or a C 6-15 aryl group which is unsubstituted or substituted with at least one substituent selected from the group consisting of a chlorine atom, a bromine atom, a methyl group, an ethyl group and a nitro group. When this derivative is reacted with a sulfonium ion-generating reagent to thereby effect an intramolecular N-glycosylation of the derivative, a β-2',3'-dideoxynucleoside derivative which is useful as a precursor of an antiviral agent, such as AZT, DDC or FLT, can be produced with an extremely high stereoselectivity for the β-anomer and in high yield while very little or none of the α-form isomer corresponding thereto is produced. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009047313-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009047314-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010222565-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101551778-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010210833-A1 |
| priorityDate | 1993-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.