| abstract |
The present invention provides anti-neoplastic topoisomerase I inhibitors of the formula: <IMAGE> wherein Ar is (C6-C12)aryl or (6- to 12-membered) heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with (C1-C4)alkyl; X is H, CN, CHO, OH, acetyl, CF3, OCH3, NO2 or NH2; each Y is individually H, (C1-C4)alkyl or aralkyl; Y' is H or (C1-C4)alkyl; n is 0 or 1; or a pharmaceutically acceptable salt therein. |