| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-785 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785 |
| filingDate |
1994-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_153b35ccc337fcb275075c7d3ab34902 |
| publicationDate |
1998-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5807582-A |
| titleOfInvention |
Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage forms made therefrom |
| abstract |
The present invention provides for an improvement in the emulsion copolymerization process for the preparation of fine-beaded colestipol hydrochloride (FBCH) wherein the improvement comprises: 1) utilizing a weight ratio of water to polyethylenepolyamine in the process of 1.8 to 3.6 grams per gram, and 2) utilizing a weight ratio of surface active agent or surfactant to polyethylenepolyamine in the process of 1.0 to 3.0 grams per kilogram. The colestipol hydrochloride product thus produced is a novel fine-beaded form of a known pharmaceutical composition, yielding pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and oral tablets. Conventional colestipol hydrochloride was heretofore available in large spherical granules which produced less elegant (gritty) oral suspensions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8889738-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8808738-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9066972-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9895315-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006177415-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9555056-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7589238-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7459502-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8425887-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005147580-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579343-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9585911-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6733780-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8163799-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8900560-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8986669-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005260236-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007110706-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7608674-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005131138-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7985418-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9931358-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006251614-A1 |
| priorityDate |
1988-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |