| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6420d04b0d68f339771080e32bd0fbc9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96461
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-975
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-827 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70539
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
1997-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c15af03d457ab90809a68be52f2ba1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de1a81e86ddf54f7f01594bddc266d9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72ff28cf9b52b4305b199da542bf81da |
| publicationDate |
1998-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5804392-A |
| titleOfInvention |
Diagnostic assays using soluble endothelial cell protein C/activated protein C receptor |
| abstract |
Plasma EPCR has been isolated, characterized and shown to block cellular protein C activation and APC anticoagulant activity. Plasma EPCR appears to be about 43,000 daltons and circulates at approximately 100 ng/ml (98.4+/-27.8 ng/ml, n=22). Plasma EPCR bound activated protein C with an affinity similar to that of recombinant soluble EPCR (Kdapp approximately 30 nM), and inhibits both protein C activation on an endothelial cell line and APC anticoagulant activity in a one-stage factor Xa clotting assay. Soluble plasma EPCR appears to attenuate the membrane-bound EPCR augmentation of protein C activation and the anticoagulant function of activated protein C. Soluble EPCR has also been detected in urine. Levels of soluble EPCR can rise in inflammatory disease associated with vascular injury and appear to be correlated with inflammation and disease states associated with abnormal coagulation. Since EPCR expression is restricted to larger vessels and is usually negative in cappillaries, these observations provide a mechanism for analyzing injury/stimulation of large vessel endothelial cells. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02066981-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02066981-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6376169-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6037450-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005032140-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011012832-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7063843-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002106634-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7282488-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9229010-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002068713-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9900673-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7169573-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2002245474-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6399064-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6953568-B1 |
| priorityDate |
1997-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |