| abstract |
PCT No. PCT/JP95/00706 Sec. 371 Date Oct. 9, 1996 Sec. 102(e) Date Oct. 9, 1996 PCT Filed Apr. 11, 1995 PCT Pub. No. WO95/27710 PCT Pub. Date Oct. 19, 1995A compound represented by formula (I): <IMAGE> (I) wherein R1 represents a hydrogen atom, a lower alkyl group or an acyl group; R2 and R3, which may be the same or different, each represents a hydrogen atom, an optionally substituted alkyl group, or an optionally substituted alkenyl group; R4 represents a hydrogen atom, an optionally substituted alkyl group, or an optionally substituted alkenyl group, or R4 forms a double bond between the carbon atom to which R3 is bonded and the adjacent carbon atom to form a benzothiophene skeleton, or R3 and R4 are taken together to form a 5- to 8-membered spiro ring which may contain a hetero atom, e.g., oxygen, sulfur or nitrogen; and n represents an integer of 0 to 2, or a pharmaceutically acceptable salt thereof. The compound of formula (I) exhibits an inhibitory action on the oxidative modification of LDL and is useful as therapeutics of arteriosclerosis. |