| abstract |
The present invention relates to a method for making a compound of the structure: <IMAGE> comprising the steps: (a) adding 6-deoxy- alpha -L-mannopyranosyl bromide, 2,3,4-tri-O-benzoate; DMSO; a base, selected from the group including tertiary amines, amidines, bicarbonates, carbonates, heteroaryl amine, and a solvent, hydrocarbons, esters, and ethers, in a slurry heated to 50 DEG -150 DEG C.; (b) stirring the reaction mixture at 50 DEG -150 DEG C. for 5 minutes to 30 minutes, (c) pouring the reaction mixture over ice water; and (d) extracting the product with a solvent selected from the group consisting of chlorinated solvents, aromatic hydrocarbons, esters, ethers, and evaporating said layer to give a solid. |