| abstract |
PCT No. PCT/US93/05792 Sec. 371 Date Feb. 17, 1995 Sec. 102(e) Date Feb. 17, 1995 PCT Filed Jun. 18, 1993 PCT Pub. No. WO94/00748 PCT Pub. Date Jan. 6, 1994Thus invention relates generally to a bioassay technique to measure the interaction of molecules with ion channels and in particular, sodium channels. More specifically, the present invention relates to the use of circular dichroism to diagnose ion channel, I. e., potassium, calcium and preferably sodium channel disease or dysfunction and a method for screening ion channel active molecules. This invention further provides a novel means to treat cancer associated with diseased dysfunction of ion channels, and especially sodium channel thermal proteins. |