| abstract |
PCT No. PCT/SG96/00004 Sec. 371 Date May 19, 1997 Sec. 102(e) Date May 19, 1997 PCT Filed May 22, 1996 PCT Pub. No. WO96/37213 PCT Pub. Date Nov. 28, 1996The use of des-Aspartate-angiotensin I (Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) as an anti-cardiac hypertrophic agent is described. The compound, given either intravenously or orally, prevented the development of experimentally-induced cardiac hypertrophy in rats. Its action was dose-dependent and the maximum anti-cardiac hypertrophic effect was obtained at a dose of(i) 180 ng/day when given intravenously, and (ii) 285 mu g/day when given orally. |