| abstract |
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following structure formula I: <IMAGE> wherein wavy line attachments indicate either the alpha (a) or beta (b) configuration; hatched lines indicate a configuration, solid triangles are used to indicate b configuration, dashed bonds represent a double bond, or a single bond; n is 0, or an integer of from 1 to 3; X is NH2 or OR; R is hydrogen, R4 or a -(CO)R4 group; R1, R2, and R3 independently are hydroxyl, or -O(CO)R5 groups, wherein R4 and R5 independently stand for saturated or unsaturated acyclic hydrocarbon having from 1 to 20 carbon atoms, or -(CH2)mR6 where m is 0-10 and R6 is an aliphatic, aromatic or heteroaromatic ring, R7 and R8 together are =O, or independently are hydrogen or alkyl of one to 6 carbon atoms or pharmaceutically acceptable salts thereof. |