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publicationNumber US-5763587-A
titleOfInvention Process for the synthesis of amikacin
abstract In the synthesis of amikacin, having the formula: <IMAGE> (I) by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economically and the synthesis yield to be improved.
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