| abstract |
This invention relates to a phenylene derivative represented by the following formula (1) or a salt thereof and also to a medicine containing it as an effective ingredient. <IMAGE> wherein R1 represents H or halogen; A represents -CH=CH-, -CH=N-, -N(R2)-, -O- or -S-; W represents -CH=CH- or -CH2O-; X represents -CH2O-, -CH2S-, -CH2N(R3)-, -CH=N-, -COO- or -CONH-; Y represents <IMAGE> <IMAGE> <IMAGE> B1 represents -C(R7)(R8)(CH2)l-, -S(O)m(CH2)n- or -CH=C(R9)-; B2 represents -CH2CH2- or -CH2CH2CH2-; Z1 and Z2 each represents O or S; etc. The phenylene derivative or salt thereof has antileukotrienic action and antihistaminic action and is useful as a medicine such as an asthma preventive or curative.\! |