| abstract |
The present invention relates to novel methods for reducing toxicity associated with the administration of conventional "D" nucleoside compounds, including anti-HIV nucleosides and related therapeutic agents. Therapeutic methods which rely on conventional "D" nucleosides exhibit unexpectedly reduced toxicity when the methods include the co-administration of effective amounts of "L" nucleoside compounds. The method are particularly useful for the treatment of HIV infections and AIDS related symptoms in humans. |