Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72574a920be630bd2d17bbef34110af2 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0005 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 |
filingDate |
1995-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
1998-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d934c5121bd0e8ac7413f19727cc9cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e33d3b2924cd3f124a0e35b3adc83549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2e65a5215f8ae3276f836433693a00d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05f0e9b4d2fe6970dd933fc748e9d5d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b9dd7b83cde5b7c2838dab34c710d1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_813859ddd54cefe54d029614e3d1f57b |
publicationDate |
1998-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-5750744-A |
titleOfInvention |
Process for the preparation of 4-amino- 4-3-ketosteroids via 4-nitro- 4-3-ketosteroids |
abstract |
PCT No. PCT/US95/04399 Sec. 371 Date Feb. 11, 1997 Sec. 102(e) Date Feb. 11, 1997 PCT Filed Apr. 11, 1995 PCT Pub. No. WO95/29932 PCT Pub. Date Nov. 9, 1995The present invention provides 4-nitro- DELTA 4-3-ketosteroids, their use as steroid C17-20 lyase and 5 alpha -reductase inhibitors and to a novel process for preparing a compound of the formula: <IMAGE> I comprising sequentially: a) reacting a starting compound of the formula <IMAGE> I with an effective amount of a strong base at an elevated or suitable temperature for a time sufficient to create the corresponding thermodynamic dienolate, followed by addition of a neutral nitrating agent to produce the 4-nitro-steroid; and then; b) reacting the 4-nitrosteroid with a suitable reducing agent. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004037843-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006247216-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004037843-A3 |
priorityDate |
1994-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |