abstract |
Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming alpha -helical or beta -sheet segments. In particular, amino acid residues known to stabilize alpha -helical and beta -sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided. |