| abstract |
Cis-epoxide compounds of formula (I-1) and pharmaceutically acceptable salts, hydrates and solvates thereof: <IMAGE> (I-1) wherein: R1 is a cycloalkyl, or aryl-substituted lower alkyl group; A is a functionalized acyl group of the formula <IMAGE> wherein R2 is a C1-4 alkyl, or amide-substituted C1-2 alkyl group; R3 is a C1-4 alkoxy, aryloxyalkyl or arylalkoxy, or a nitrogen-containing aromatic radical, or a lower alkoxy group substituted with a nitrogen-containing aromatic radical, or a radical having the formula of <IMAGE> wherein R4 is a hydrogen or a methyl group and R5 is an alkyl group substituted with a nitrogen-containing aromatic radical; and m is 0 or 1; and B is a functionalized amino group of the formula <IMAGE> wherein R8 and R9 are independently a C1-4 alkyl group optionally substituted with an aromatic radical, or an aromatic group. |