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grantDate 1998-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1998-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5741681-A
titleOfInvention Method for producing L-aspartic acid
abstract PCT No. PCT/JP95/02526 Sec. 371 Date Aug. 8, 1996 Sec. 102(e) Date Aug. 8, 1996 PCT Filed Dec. 8, 1995 PCT Pub. No. WO96/17950 PCT Pub. Date Jun. 13, 1996L-aspartic acid is produced by repeating the following respective steps: (1) a reaction step of producing ammonium L-aspartate from an aqueous solution containing monoammonium maleate in accordance with an isomerization reaction and an enzyme reaction caused by aspartase in the presence of ammonia; (2) an ammonia-eliminating step of converting substantially all produced ammonium L-aspartate into monoammonium salt by distilling or stripping a reaction solution obtained in the step (1); (3) a crystallization step of crystallizing L-aspartic acid and producing monoammonium maleate from a solution obtained in the step (2) by adding maleic acid, maleic anhydride or both; (4) a solid-liquid separation step of separating L-aspartic acid crystals precipitated in the step (3) from a mother liquor containing monoammonium maleate; and (5) a recycle step of supplying the mother liquor containing monoammonium maleate obtained in the step (4) to the step (1) to be used as a raw material for the reaction.
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