| abstract |
Disclosed herein is a method of treating a disease of the central nervous system with a compound of the formula <IMAGE> in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is -CO2H or tetrazolyl, Y is -CH=CH-, and Z is (i) phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, (ii) -CHR1R2 where R1 and R2 are each phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, (iii) =CR1R2 where R1 and R2 are each phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, or (iv) <IMAGE> where r is 0 or 1 to 3 and the phenyl rings are optionally substituted; provided that when Z is phenyl and m is 1, p is 1; and salts and esters thereof. |