| abstract |
PCT No. PCT/EP95/00626 Sec. 371 Date Nov. 25, 1996 Sec. 102(e) Date Nov. 25, 1996 PCT Filed Feb. 20, 1995 PCT Pub. No. WO95/23127 PCT Pub. Date Aug. 31, 1995Compounds of the formula I <IMAGE> I including pharmaceutically acceptable salts thereof are disclosed in which R1, R2, R3, and R4 independently represent hydrogen, hydroxy, halo, halogenated alkyl, halogenated alkoxy, alkyl, alkoxy, cyano, a carbamoyl group, carbonyl group, or R1 and R2 together with the phenyl ring represent a naphthalene ring (optionally substituted); L1 represents C2-6 alkylene; R5 represents hydrogen or alkyl, R6 represents hydrogen or alkyl, phenylalkyl (optionally substituted) or R5 and R6 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring; L2 represents a C1-6 alkylene chain; and R7 and R8 independently represent hydrogen or alkyl or R7 and R8 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring. The compounds are anti-inflammatory and/or anti-allergic agents and/or immunomodulants useful in treating rheumatic diseases and/or neurological damage. Compositions containing these compounds and processes to make then are also disclosed. |