| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a6a9431aa1fe5109ca95ad4e332231b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-18 |
| filingDate |
1995-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd71d901d3bfca3b707e84f7aa4c5156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaf5f0d2da01cd647d1b4d63770db43d |
| publicationDate |
1998-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5736148-A |
| titleOfInvention |
Infectious Japanese encephalitis virus cDNA clones that produce highly attenuated recombinant Japanese encephalitis virus, and vaccines thereof |
| abstract |
cDNA clones containing the entire genome of Japanese encephalitis virus (JEV) were used to produce infectious, recombinant JEV particles with diverse virulence properties. Certain viruses retained the immunogenicity of JEV, but lacked the ability to cause encephalitis. The mutation associated with this loss of neurovirulence was localized to a nucleotide substitution in the codon encoding the 138th amino acid of the envelop protein, resulting in a mutation of an acidic amino acid to a basic amino acid. Attenuated viruses containing this mutation form the basis of a greatly improved, molecularly defined vaccine for the prevention of Japanese encephalitis in humans. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003194801-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02072835-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10369209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7785799-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006159704-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008268423-A1 |
| priorityDate |
1993-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |