http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5731442-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ce023a6c13740cb05a67332f11a29f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-48 |
| filingDate | 1997-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcfec8cf58bbbc1177a6252f75cd8afc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56ecce5591a3249269b2b89c555bbc1d |
| publicationDate | 1998-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5731442-A |
| titleOfInvention | Synthesis of thiazole derivatives |
| abstract | N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine--a key intermediate for preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable. |
| priorityDate | 1997-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.