http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5731435-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56666880a5e2b7703e98a4f9b2d9daf6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-15 |
| filingDate | 1995-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84a0eabbc78cc7740e7cc4eff4e59425 |
| publicationDate | 1998-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5731435-A |
| titleOfInvention | Process for the preparation of heterocyclic alkylamide derivatives |
| abstract | The present invention relates to a novel process for the preparation of N-heterocyclealkanamide derivatives having the following formula: ##STR1## which comprises reacting 1-(2-chloroethyl)piperidine with 2-chlorobenzeneacetonitrile to give (±)-α-(2-chlorophenyl)-1-piperidinebutanenitrile; alkylating the piperidenebutanenitrile to give (±)-α-(2-chlorophenyl)-α-(2,2-dimethoxyethyl)piperidine-1-butanenitrile; hydrolyzing the resulting alkylated piperidinebutanenitrile to give (±)-α-(2-chlorophenyl)-α-(2-oxoethyl)piperidine-1-butanenitrile; reacting the resulting piperidinebutanenitrile with isopropylamine to form (±)-α-(2-chlorophenyl)-α- 2- (1-methylethyl)imino!ethyl!piperidine-1-butanenitrile; reducing the resulting imine to form (±)-α-(2-chlorophenyl)-α- 2- (1-methylethyl)amino!ethyl!-piperidine-1-butanenitrile; acetylating the resulting amine to form (±)-N- 3-(2-chlorophenyl)-3-cyano-5-(1-piperidinyl)pentyl!-N-(1-methylethyl)acetamide; hydrolyzing the resulting acetylated amino substituted piperidine butanenitrile to form (±)-α- 2- acetyl(1-methylethyl)amino!ethyl!-α-(2-chlorophenyl)-1-piperidinebutanamide; and isolating the resulting piperidinebutanamide. |
| priorityDate | 1995-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.