| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8121
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-8125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate |
1994-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10d5d20ebb4321033dab4c0ff5775e8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cebbaa05fdd9995d5e3c40aa927b2f2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c66fc406611f970d50fe6d06b250791b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c565f09ce08096294e933a634d20e951 |
| publicationDate |
1998-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5723316-A |
| titleOfInvention |
α-1-antichymotrypsin analogues having chymase inhibiting activity |
| abstract |
The invention provides analogues of alpha -1-antichymotrypsin having amino acid substitutions at position 358. alpha -1-antichymotrypsin analogues having amino acid substitutions at positions 356-361 and analogues having amino acid substitutions at positions 356-361 wherein the amino acid at position 358 is substituted are also within the scope of the invention. These analogues exhibit chymase inhibitory activity. Also provided are novel alpha -1-antichymotrypsins having an N-terminal extension of methionine-alanine-serine or alanine-serine. Expression vectors for the production of alpha -1-antichymotrypsins are also provided. The present invention also provides host cells and cell cultures capable of expressing analogues of alpha -1-antichymotrypsin, as well as protein preparations from the host cells. Methods of producing and using the analogues of alpha -1-antichymotrypsin to inhibit chymase activity are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006148833-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1410798-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1410798-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1798838-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004191239-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003017145-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5827662-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004018984-A1 |
| priorityDate |
1989-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |