http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5723300-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a517102b0f21068b1fc7cc0e59d0073 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57426 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate | 1995-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14c8b7b0d068ff5278376234bbee8c2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f52ccb5b245e406fbe0429536c5b72a |
| publicationDate | 1998-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5723300-A |
| titleOfInvention | Nuclear localized transcription factor kinase and diagnostic assays related thereto |
| abstract | New nuclear kinases that are regulated by signal transduction and that participate in phosphorylation cascades which regulate transcription and related methods for regulating transcription. The novel nuclear kinases play a vital role in gene expression, particularly with regard to leukemia in humans. The kinase is (i) substantially exclusively intranuclearly localized; (ii) capable of autophosphorylation; (iii) selectively bindable with antibodies raised against the RING3 portion of GST-RING3; (iv) of a molecular weight of from about 82.5 to about 92.7 kilodaltons; and (v) includes peptide sequences Asp-Ser-Asn Pro-Asp-Glu-Ile-Glu-Ile-Asp-Phe-Glu-Thr-Leu-Lys-Pro-Thr-Thr-Leu (SEQ ID NO: 1) and Ala-Val-His-Glu-Gln-Leu-Ala-Ala-Leu-Ser-Gln-Ala-Pro (SEQ ID NO: 2). The invention features a method of detecting leukemic cells in a biological sample, the method includes measuring the activity of a RING3-related kinase in the sample, an increase in the activity relative to a control being indicative of the presence of leukemic cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006263826-A1 |
| priorityDate | 1995-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.