| abstract |
The present invention relates to compounds of formula (I) wherein: R 1 , R 2 , R 3 , R 4 and R 5 are selected from a variety of suitable aromatic substituents; R 6 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, or C 2 -alkyl substituted by C 1-4 alkoxy or hydroxy; R 7 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, C 2-4 alkyl substituted by C 1-4 alkoxy or hydroxy, or the group C(═NR c )NR a R b ; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form an optionally substituted saturated heterocyclic ring of 4 to 7 ring atoms which may optionally contain in the ring one oxygen or sulphur atom or a group selected from NR 8 , S(O) or S(O) 2 ; or R 6 and R 7 , together with the nitrogen atom to which they are attached, form a piperidino ring substituted by a spiro-fused indene or indoline group, each of which may be unsubstituted or substituted; R 8 is hydrogen, C 1-4 alkyl, hydroxyC 1-4 alkyl or C 1-4 alkoxyC 1-4 alkyl; R 9a and R 9b are each independently hydrogen or C 1-4 alkyl, or R 9a and R 9b are joined so, together with the carbon atoms to which they are attached, there is formed a C 5-7 ring; X is selected from --CH 2 CH 2 --, --COCH 2 -- or --CH 2 CO--; and Y is hydrogen, or C 1-4 alkyl optionally substituted by a hydroxyl group; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. ##STR1## |