http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5710283-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba045776bcd32d32e3100da8dfce4e28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-26 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 |
| filingDate | 1996-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4770189f50f68627d4401bc7cc03ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_567a4e2afabf53ad7bfd53f09f923c0d |
| publicationDate | 1998-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5710283-A |
| titleOfInvention | Preparation of chiral pyrrolidinone derivatives |
| abstract | A process for preparing a compound of formula IIa or IIb: ##STR1## wherein R 2 , R 3 , R 4 and R 5 independently represent hydrogen or C 1 -C 4 alkyl; and n A is an optionally substituted aromatic or heteroaromatic ring system; the process comprising the steps of: n (a) reacting a racemic mixture of a compound of formula II: ##STR2## wherein R 2 , R 3 , R 4 , R 5 and A are as defined for formulae IIa and IIb; with a sterically hindered chiral esterifying agent to form enantiomers of formulae IIIa and IIIb: ##STR3## wherein R 2 , R 3 , R 4 , R 5 and A are as defined for formulae IIa and IIb and R 15 is a chiral sterically hindered residue; n b) separating the diastereoisomers of formulae IIIa and IIIb; and n (c) converting the diastereoisomers of formulae IIIa and IIIb separately to compounds of formulae IIa and IIb respectively by acid or base hydrolysis. If required, the unwanted enantiomer of formula IIa or IIb may be inverted to give the preferred isomer. |
| priorityDate | 1995-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 199.