| abstract |
PCT No. PCT/JP94/01342 Sec. 371 Date Aug. 5, 1995 Sec. 102(e) Date Aug. 5, 1995 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05177 PCT Pub. Date Feb. 23, 1995Disclosed is an agent for curing neuronal diseases caused by disorders of peripheral nervous system or central nervous system, which comprises a 2-acylaminopropanol derivative represented by the formula (I): <IMAGE> (I) [wherein R1 represents a phenyl group or cyclohexyl group each of which may be substituted by 1 to 3 same or different substituents selected from the group consisting of alkyl, alkoxy, hydroxy and nitro, or represents an alkyl group, and n represents an integer of 0 to 16] or a pharmaceutically acceptable salt thereof as an effective ingredient. It accelerates neurite extension and synapse formation by elevating biosynthesis of endogenous sphingoglycolipid of neurocytes, particularly ganglioside, whereby it can be used for curing various diseases of central nervous system and peripheral nervous system. |