| abstract |
The invention relates to novel cyclopeptides of the formula I n n cyclo-(A-B-C-D-Arg) I n n in which n A and B are each independently of one another Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val; n C is Asp or Asp(O--C 1-4 -alkyl); and n D is Gly or Ala; n at least two of the amino acid radicals stated being present in the D-form; n and their salts. n These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation and in tumor therapy. |