http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5703072-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e06d8df5ecb58e082a70a2bd8c474836 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1996-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06bf4c7aa4223ac2ce144e591f2b931a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33971e79aa033544af2dba7c3cc989cd |
| publicationDate | 1997-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5703072-A |
| titleOfInvention | Bicyclic nonane and decane compounds having dopamine receptor affinity |
| abstract | Described herein are D4 receptor-selective compounds of the general formula: <IMAGE> wherein: A and B are independently selected, substituted or unsubstituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from O, S, SO, SO2, CH2, C=O, CH-OH, CH-N(C1-4alkyl)2, C=CHCl, and C=CHCN; X2--- is selected from N=, CH2-, CH= and C(O)-; n is 1 or 2; R1 is selected from H and the alpha -carbon side chain of an amino acid; R2 and R3 are selected independently from H, OH, -NH2, -C(O)NH2=O, =S,halo,cyano, C1-9alkyl, C1-9alkoxy, C1-4alkylS-, C1-4alkylSO-, C1-4alkylSO2-, phenoxy, benzyloxy and piperonyloxy; and H* is in either the R- or the S-configuration, and acid addition salts, solvates and hydrates thereof. Their use as ligands for dopamine receptor identification and in a drug screening program, and as pharmaceuticals to treat indications in which the D4 receptor is implicated, such as schizophrenia, is also described. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003135042-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6890919-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005222121-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0132659-A1 |
| priorityDate | 1994-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 208.