Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-38 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4535 |
filingDate |
1995-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
1997-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0739a1b45fc19a4e08769aad4877e73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa380a6864e01a4f39b69cef5cadad4f |
publicationDate |
1997-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-5700815-A |
titleOfInvention |
Methods of increasing thrombomodulin expression |
abstract |
A method of increasing thrombomodulin expression comprising administering to a human in need of treatment an effective amount of a compound having the formula <IMAGE> (I) wherein R1 and R3 are independently hydrogen, <IMAGE> wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof. wherein R1 and R3 are independently hydrogen, <IMAGE> wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidino, hexamethyleneimino, and piperidino; and pharmaceutically acceptable salts and solvates thereof. Also encompassed by the invention is a method of inhibiting a thrombotic disorder or event which includes administering to a human in need thereof an effective amount of a compound of formula 1. Also encompassed by the invention is a method of increasing Protein C activation rate which includes the administration of a compound of formula 1. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010303800-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8293231-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6630453-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5843974-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6562862-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007135360-A1 |
priorityDate |
1993-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |