abstract |
This invention provides a compound having the structure: ##STR1## wherein R 1 , R 2 , and R 3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH 2 or CF 2 ; R is chlorine, bromine, iodine, carbonitrile, carboxylic ester, or carboxamide; and one of W, X and Y is N or N + R', wherein R' is methyl or ethyl, and all others are CH; provided that R 1 is not H when R 2 and R 3 are OH, Z is O, R is carboxamide and W is N or N + R'. n This invention also provides methods of preparing the compounds and a method of treating a mammal having a NAD-dependent enzyme associated disorder. |