| abstract |
This invention relates to compounds of the formula <IMAGE> Formula I where R1 and R2 are both hydrogen or R1 and R2 form a bond; m=1 and n=3 and p=6, or m=3, 5 or 7 and n=1 and p=6, or m=4 and n=2 and p=6 or 8, and the E (trans) and Z (cis) isomers when R1=R2=H; and the basic addition salts thereof which are inhibitors of phospholipase A2 and are thus useful agents in the treatment of inflammatory diseases where arachidonic acid metabolic products are implicated, such as rheumatoid arthritis, inflammatory bowel diseases such as ulcerative colitis, atopic dermatitis conditions such as psoriasis and immediate hypersensitivity reactions such as allergic bronchial asthma and allergic rhinitis; and as gastric cytoprotective agents. |