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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
filingDate 1996-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1997-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d02e51f3f00f89a07a0262a39ed3132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f93cf0650a0a8cd101684407a3dc346
publicationDate 1997-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5677422-A
titleOfInvention Method for making a polypeptide derivative
abstract A method for making a homogeneous succinylated polypeptide is disclosed. The method can be carried out by adding a succinyl-containing compound to a polypeptide solution, followed by raising the pH of the polypeptide solution to a pH of between about pH 10 to pH 12.5. The succinylation reaction between the succinyl-containing compound and free amino groups of the polypeptide is essentially complete upon raising the polypeptide solution pH to the alkaline pH.
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priorityDate 1994-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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