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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
filingDate 1993-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1997-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b52f520475f2b6a32f81eec0281bdad5
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publicationDate 1997-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5676927-A
titleOfInvention Granular preparation for MRI
abstract PCT No. PCT/JP93/01658 Sec. 371 Date May 12, 1995 Sec. 102(e) Date May 12, 1995 PCT Filed Nov. 12, 1993 PCT Pub. No. WO94/11033 PCT Pub. Date May 26, 1994The present invention relates to a granular preparation for MRI obtained by granulating a viscosity-increasing agent together with a binder and if necessary, a vehicle, a disintegrant, etc., by the use of a fluidized-bed granulation method, and spraying ferromagnetic particles suspended in an aqueous solution of a viscosity-increasing agent or a binder for coating the granules or incorporating the suspension into he granules at the time of granulation to prepare bulky granules. The granular preparation according to the present invention does not undergo coagulation due to gelling at the time of suspending, and can be instantaneously turned into a suspension which is uniform and viscose by mere stirring. Accordingly, the preparation method is simple and easy. Since it is a solid preparation, stability of the ferromagnetic particle is higher than that of an aqueous dispersion, it is free from the problem of putrefaction by microorganisms and molds and is advantageous from the aspects of transportation and storage space.
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