http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5668001-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75a4e06071f555a5c6ef8893d2aff09e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-60 |
| filingDate | 1994-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_538e7d349494fadb21ee9192dcc04a1a |
| publicationDate | 1997-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5668001-A |
| titleOfInvention | 3-hydroxy-3-methyl-glutaryl-coa synthase preparation with improved stability |
| abstract | A preparation of recombinant 3-hydroxy-3-methylglutaryl-CoA synthase is disclosed, wherein the preparation has at least 0.024 units/mg specific activity. Preferably, the preparation has at least 0.24 units/mg specific activity and is a crude cell extract. Preferably, at least 90% of the synthase molecules have not been substantially proteolytically cleaved. A preparation of recombinant HMG-CoA synthase wherein the preparation retains 50% activity after storage at 4 DEG C. for six months is also disclosed. A method of evaluating the efficacy of candidate anti-isoprene and anti-cholesterol drugs is also disclosed which comprises exposing the candidate drug to a recombinant 3-hydroxy-3-methylglutaryl CoA synthase preparation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005164245-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006292563-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03103597-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03103597-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004058338-A1 |
| priorityDate | 1993-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.