| abstract |
Platinum complexes of formula Ia or Ib <IMAGE> Ia <IMAGE> Ib where each A, is a leaving group and may be the same or different, which is suitably halo, especially chloro, hydroxy, carboxylate or together form a bi-dentate carboxylate or sulphate, each B, which may be the same or different, is halo, hydroxy, carboxylate, carbamate or carbonate ester, Z is a substituted amine wherein the substituent sterically hinders access of the Pt atom to a DNA strand of a tumour cell, and X is NH3 or mono- or di-alkyl substituted NH3, are active against cancer cells, and appear to show a unique form of chemical and biological action. |